Variables associated with the development of hyperoxia in subjects with invasive mechanical ventilation: a retrospective analysis
Abstract
Objective: To analyze whether clinical-demographic, laboratory, or ventilator setting variables are associated with the presence of hyperoxia during the first 24 hours of invasive mechanical ventilation (IMV). The secondary objective was to describe the course of hyperoxia and arterial oxygen partial pressure (PaO₂) during the first week of IMV.
Materials and methods: An observational, analytical, retrospective study was conducted. Subjects older than 18 years with more than 12 hours of IMV were included. Clinical-demographic variables at admission were recorded. Ventilator setting variables and arterial blood gases were recorded during the first week. The primary outcome variable was the presence of hyperoxia, and the secondary outcome variable was the course of hyperoxia during the first week. Hyperoxia was defined as PaO₂ > 100 mmHg.
Results: A total of 116 subjects were analyzed, of whom 55 (47.4 %) had hyperoxia during the first 24 hours of IMV. On day 7 of IMV, 23 subjects (19.8 %) remained mechanically ventilated; of these, 5 (21.7 %) had hyperoxia. Multivariate logistic regression analysis showed that arterial carbon dioxide pressure (PaCO₂) was independently associated with a lower probability of hyperoxia (OR 0.92; 95 % CI: 0.87–0.97).
Conclusion: Higher PaCO₂ values were associated with a lower probability of developing hyperoxia. The frequency of subjects with hyperoxia decreased during the first week of IMV.
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