Setting and use of a mechanical insufflator–exsufflator in pediatrics
Abstract
The mechanical insufflator-exsufflator (MI-E) is a device that gradually applies positive pressure to the airway, followed by rapid change to negative pressure, facilitating an effective cough. It is especially indicated in subjects who, due to respiratory muscle disorders, are unable to achieve an effective peak cough flow (PCF), which is essential to adequately eliminate secretions. The MI-E can be used through a face mask, oral pipette, or tracheostomy tube. Studies on children with neuromuscular disease have shown that the device is safe and well tolerated, causes an increase in the PCF, decreases the need for respiratory therapy, facilitates extubation, and reduces the frequency of exacerbations or recurrent acute events. The indication and use of the MI-E is increasingly frequent. Therefore, it is essential to know its characteristics, setting, and indications for use in the pediatric population.
References
Panitch H. Respiratory implications of pediatric neuromuscular disease. Respir Care. 2017; 62(6):826-848.
Mozzoni J; Gomez S. Uso del asistente mecánico de la tos en sujetos neuromusculares pediátricos en el domicilio. Argentinian Journal of Respiratory & Physical Therapy, 2020, vol. 2, no 2, p. 20-28.
Toussaint M, Chatwin M, Gonzalez J, Berlowitz DJ. ENMC international workshop: airway clearance techniques in neuromuscular disorders, Naarden, The Netherlands, 3-5 March, 2017. Neuromuscul Disord.2018; 28:289-298.
Chatwin M, Toussaint M, Goncalves M, Sheers N, Mellies U, Gonzales- Bermejo J, et al. Airway clearance techniques in neuromuscular disorders: a state of the art review. Respir Med. 2018; 136:98-110.
Camela F, Gallucci M, Ricci G. Cough and airway clearance in Duchenne muscular dystrophy. Paediatr Respir Rev. 2019; 31:35-39.
Finkel R, Iannaccone S, Crawford T, Woods S, Muntoni F, Wirth B, et al. Diagnosis and management of Spinal Muscular Atrophy: Part 2: pulmonary and acute care; medications, supplements and immunizations, other organ systems and ethics. Neuromuscul Disord. 2017; 28(3):197-207.
Hull J, Aniapravan R, Chan E, Chatwin M, Forton J. Gallagher J et al. British thoracic society guideline for respiratory management of children with neuromuscular weakness. Thorax. 2012; 67:i1-i40.
Miske L, Hickey E, Kolb S, Weiner D, Panitch H. Use of the mechanical In-Exsufflator in pediatric patients with neuromuscular disease and impaired cough. Chest. 2004; 125:1406-1412.
Fauroux B, Guillemot N, Aubertin G, Nathan N, Labit A, Clement A, Lofaso F. Physiologic benefits of mechanical Insufflation-Exsufflation in children with neuromuscular diseases. Chest. 2008; 133:161-168.
Chatwin M, Simonds A. The addition of mechanical Insufflation-Exsufflation shortens airway clearance sessions in neuromuscular patients with chest infection. Respir Care. 2009; 54(11):1473-1479.
Bach J, Sinquee D, Saporito L, Botticello A. Efficacy of mechanical Insufflation-Exsufflation in extubating unweanable subjects with restrictive pulmonary disorders. Respir Care. 2015; 60(4):477-483.
Chatwin M, Simonds A. Long-term mechanical Insufflation-Exsufflation cough assistance in neuromuscular disease: patterns of use and lessons for application. Respir Care. 2020; 65(2):135-143.
Bento J, Goncalves M, Silva N, Pinto T, Marinho A, Winck J. Indicaciones y cumplimiento con la insuflación – exsuflación mecánica domiciliaria en pacientes con enfermedades neuromusculares. Arch Bronconeumol. 2010; 46(8):420-425.
Chatwin M. "How to use a mechanical insufflator–exsufflator “cough assist machine”." Breathe 4.4, 2008: 320-329.
Hov B, Andersen T, Hovland V, Toussaint M. The clinical use of mechanical Insufflation-Exsufflation in children with neuromuscular disorders in Europe. Paediatr Respir Rev. 2018; 27:69-73.










