Early physical therapy could be associated with the absence of functional disability at 24-month follow-up in children with juvenile idiopathic arthritis

An observational and retrospective study

Authors

    Juan Pablo Ford 1 , Soledad Gomez Heil 2

    1 Hospital J. P. Garrahan
    2 Hospital J. P. Garrahan

Abstract

 

Objective: To identify the variables associated with the absence of functional disability 24 months after the start of physical therapy (PT) in children with juvenile idiopathic arthritis (JIA).

Materials and method: An observational, analytical and retrospective study was conducted. Children aged from 1 to 16 years with JIA were admitted. Functional ability was assessed using the Childhood Health Assessment Questionnaire. Univariate and multivariate analyses were performed to determine the factors associated with functional disability at 24-month follow-up. A p-value <0.05 was considered significant.

Results: A total of 122 subjects met the inclusion criteria. Multivariate analysis showed that performing PT (6.83 ADJOR [95% CI 2.26 – 20.61]; p=0.001), performing PT within 12 months following the diagnosis (5.45 ADJOR [95% CI 1.83 to 16.18]; p= 0.002), baseline pain visual analogue scale (pVAS) <3 (4.55 ADJOR [95% CI 1.58 to 13.12]; p= 0.005), and pharmacological treatment adherence (15.23 ADJOR [95% CI 1.86 to 124.8]; p= 0.011) were independent factors of the absence of functional disability at 24-month follow-up.

Conclusion: Performing PT, performing early PT, baseline pVAS <3, and pharmacological treatment adherence were independently associated with the absence of functional disability at 24-month-follow-up. These results reinforce the need for early and regular PT and pharmacological treatment in children with JIA to maintain or improve functional ability over time.

References

Southwood TR, Woo P. Childhood arthritis: the name game. Br J Rheumatol. 1993 May;32(5):421-3.

Oen KG, Cheang M. Epidemiology of chronic arthritis in childhood. Semin Arthritis Rheum. 1996 Dec;26(3):575-91.

Saurenmann RK, Rose JB, Tyrrell P, Feldman BM, Laxer RM, Schneider R, Silverman ED. Epidemiology of juvenile idiopathic arthritis in a multiethnic cohort: ethnicity as a risk factor. Arthritis Rheum. 2007 Jun;56(6):1974-84.

van der Net J, Kuis W, Prakken AB, Lukkassen I, Sinnema G, Hutter AP, et al. Correlates of disablement in systemic onset juvenile chronic arthritis. A cross sectional study. Scand J Rheumatol. 1997;26(3):188-96.

Tennant A, Kearns S, Turner F, Wyatt S, Haigh R, Chamberlain MA. Measuring the function of children with juvenile arthritis. Rheumatology (Oxford). 2001 Nov;40(11):1274-8.

Cuttica R, Cervetto V, De Cunto C. Guías Prácticas Clínicas de Artrítis Idiopática Juveníl. [Internet]. 2011. [citado diciembre 2020]. Disponible en https://es.scribd.com/document/373653637/guias-practica-clinica-artritis-idiopatica-juvenil-2011-pdf

Cassidy JT, Levinson JE, Bass JC, Baum J, Brewer EJ Jr, Fink CW, et al. A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis. Arthritis Rheum. 1986 Feb;29(2):274-81.

Takken T, Van Brussel M, Engelbert RH, Van Der Net J, Kuis W, Helders PJ. Exercise therapy in juvenile idiopathic arthritis: a Cochrane Review. Eur J Phys Rehabil Med. 2008 Sep;44(3):287-97.

Ravelli A, Martini A. Early predictors of outcome in juvenile idiopathic arthritis. Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S89-93.

Magni-Manzoni S, Pistorio A, Labò E, Viola S, Garcia-Munitis P, Panigada S, et al. A longitudinal analysis of physical functional disability over the course of juvenile idiopathic arthritis. Ann Rheum Dis. 2008 Aug;67(8):1159-64.

Feldman DE, De Civita M, Dobkin PL, Malleson PN, Meshefedjian G, Duffy CM. Effects of adherence to treatment on short-term outcomes in children with juvenile idiopathic arthritis. Arthritis Rheum. 2007 Aug 15;57(6):905-12.

Singh-Grewal D, Schneiderman-Walker J, Wright V, Bar-Or O, Beyene J, Selvadurai H, et al. The effects of vigorous exercise training on physical function in children with arthritis: a randomized, controlled, single-blinded trial. Arthritis Rheum. 2007 Oct 15;57(7):1202-10.

Sandstedt E, Fasth A, Eek MN, Beckung E. Muscle strength, physical fitness and well-being in children and adolescents with juvenile idiopathic arthritis and the effect of an exercise programme: a randomized controlled trial. Pediatr Rheumatol Online J. 2013 Feb 22;11(1):7.

Hackett J, Johnson B, Parkin A, Southwood T. Paediatric rheumatology: clinical practice review. Physiotherapy and occupational therapy for juvenile chronic arthritis: custom and practice in five centres in the UK, USA and Canada. Br J Rheumatol. 1996 Jul;35(7):695-9.

Moroldo MB, De Cunto C, Hübscher O, Liberatore D, Palermo R, Russo R, Giannini EH. Cross-cultural adaptation and validation of an Argentine Spanish Version of the Stanford Childhood Health Assessment Questionnaire. Arthritis Care Res. 1998 Oct;11(5):382-90.

Ringold S, Angeles-Han ST, Beukelman T, Lovell D, Cuello CA, Becker ML, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. Arthritis Rheumatol. 2019 Jun;71(6):846-863.

Ruperto N, Ravelli A, Levinson JE, Shear ES, Murray K, Link Tague B, et al. Long-term health outcomes and quality of life in American and Italian inception cohorts ofpatients with juvenile rheumatoid arthritis. II. Early predictors of outcome.J Rheumatol1997; 24: 952–8.

Dempster H, Porepa M, Young N, Feldman BM. The clinical meaning of functional outcome scores in children with juvenile arthritis. Arthritis Rheum 2001; 44: 1768–74.

Ravelli A, Viola S, Ruperto N, Corsi B, Ballardini G, Martini A. Correlation between conventional disease activity measures in juvenile chronic arthritis. Ann Rheum Dis1997; 56: 197–200.

Mcerlane F, Beresford MW, Baildam EM, Chieng A, Davidson JE, Foster HE, et al. Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis. Ann Rheum Dis 2013; 72: 1983–1988.

Quiles MJ, van-der Hofstadt CJ, Quiles Y. Instrumentos de evaluación del dolor en pacientes pediátricos: una revisión (2ª parte). Rev Soc Esp Dolor 2004; 11: 360-369.

Faces Pain Scale – Revised, ©2018, International Association for the Study of Pain. [Internet]. 2018. [citado diciembre 2020]. Disponible en: https://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1519

Ekstrom RA, Donatelli RA, Carp KC. Electromyographic analysis of core trunk, hip, and thigh muscles during 9 rehabilitation exercises. J Orthop Sports Phys Ther. 2007;37(12):754-762.

Fischer JE, Bachmann LM, Jaeschke R. A readers' guide to the interpretation of diagnostic test properties: clinical example of sepsis. Intensive care medicine. 2003;29(7): 1043-51.

Wallace CA, Giannini EH, Spalding SJ, Hashkes PJ, O'Neil KM, Zeft AS, et al. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2012; 64(6): 2012–21.

Pouchot J, Ecosse E, Coste J, Guillemin F. Validity of the childhood health assessment questionnaire is independent of age in juvenile idiopathic arthritis. Arthritis Rheum 2004; 51: 519–26.

Husted JA, Tom BD, Farewell VT, Schentag CT, Gladman DD. Description and prediction of physical functional disability in psoriatic arthritis: a longitudinal analysis using a Markov model approach. Arthritis Rheum 2005; 53: 404–9.

Leppe Zamora J, Lecaros Vergara MJ, Manzano Tupper G, Castro AM, Núñez Herrera D. Medidas de resultados (outcomes) utilizados en la Investigación del tratamiento kinésico de la osteoartritis de rodilla. Kinesiologia 2012; 31(1): 514.

Magni-Manzoni S, Rossi F, Pistorio A, Temporini F, Viola S, Beluffi G, et al. Prognostic factors for radiographic progression, radiographic damage, and disability in juvenile idiopathic arthritis. Arthritis Rheum 2003; 48: 3509–17.

Ravelli A, Ioseliani M, Norambuena X, Sato J, Pistorio A, Rossi F, et al. Adapted versions of the Sharp-van der Heijde scoring method are reliable and valid for the assessment of radiographic progression in juvenile idiopathic arthritis. Arthritis Rheum 2007; 56: 3087–95.

Viola S, Felici E, Magni-Manzoni S, Pistorio A, Buoncompagni A, Ruperto N, et al. Development and validation of a clinical index for assessment of long-term damage in juvenile idiopathic arthritis. Arthritis Rheum 2005; 52: 2092–102.

Published

2021-07-01

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1.
Ford JP, Gomez Heil S. Early physical therapy could be associated with the absence of functional disability at 24-month follow-up in children with juvenile idiopathic arthritis: An observational and retrospective study. AJRPT. 2021;3(2):22-30. doi: 10.58172/ajrpt.v3i2.167