High flow nasal cannula in infants with obstructive sleep apnea hypopnea syndrome
A case series
Abstract
Introduction: The obstructive sleep apnea hypopnea syndrome (OSAHS) has a variable prevalence in children and can lead to multiple long-term complications if adequate treatment is not received. The current treatment is the use of continuous positive airway pressure (CPAP). This therapy, however, has a low tolerance and adherence in young children. The objective of this study is to describe the use of the high-flow nasal cannula (HFNC) as an alternative for symptomatic treatment in four infants with OSAHS.
Case presentation: Four infants aged 1 to 6 months with low weight and severe OSAHS received HFNC treatment during sleep and wakefulness. The device was placed during hospitalization, which increased the flow until reaching 2 L/min per kilo of weight, without supplemental oxygen. The four subjects showed improved symptoms, gained weight, and were discharged for home treatment (CPAP in three subjects and a tracheostomy in one subject).
Conclusion: We described the use of the HFNC in four infants with OSAHS during hospitalization. All subjects gained body weight and were discharged after achieving a transition to other treatments.
References
Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, et al. American Academy of Pediatrics. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012 Sep;130(3):576-84.
Bixler EO, Vgontzas AN, Lin HM, Liao D, Calhoun S, Vela-Bueno A, et al. Sleep disordered breathing in children in a general population sample: prevalence and risk factors. Sleep. 2009 Jun;32(6):731-6.
Guilleminault C, Li KK, Khramtsov A, Pelayo R, Martinez S. Sleep disordered breathing: surgical outcomes in prepubertal children. Laryngoscope. 2004 Jan;114(1):132-7.
Marcus CL, Rosen G, Ward SL, Halbower AC, Sterni L, Lutz J, et al. Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apnea. Pediatrics. 2006 Mar;117(3):e442-51.
O'Donnell AR, Bjornson CL, Bohn SG, Kirk VG. Compliance rates in children using noninvasive continuous positive airway pressure. Sleep. 2006 May;29(5):651-8.
Amaddeo A, Khirani S, Frapin A, Teng T, Griffon L, Fauroux B. High-flow nasal cannula for children not compliant with continuous positive airway pressure. Sleep Med. 2019 Nov;63:24-28.
McGinley B, Halbower A, Schwartz AR, Smith PL, Patil SP, Schneider H. Effect of a high-flow open nasal cannula system on obstructive sleep apnea in children. Pediatrics. 2009 Jul;124(1):179-88.
Chakravorty S, Finder JD. Positive Airway Pressure Therapy in Children. Sleep Med Clin. 2010 Sep;5(3):439–49.
Ignatiuk D, Schaer B, McGinley B. High flow nasal cannula treatment for obstructive sleep apnea in infants and young children. Pediatr Pulmonol. 2020 Oct;55(10):2791-2798.
Hawkins S, Huston S, Campbell K, Halbower A. High-Flow, Heated, Humidified Air Via Nasal Cannula Treats CPAP-Intolerant Children With Obstructive Sleep Apnea. J Clin Sleep Med. 2017 Aug 15;13(8):981-989.
Joseph L, Goldberg S, Shitrit M, Picard E. High-Flow Nasal Cannula Therapy for Obstructive Sleep Apnea in Children. J Clin Sleep Med. 2015 Sep 15;11(9):1007-10.
Castro-Codesal ML, Olmstead DL, MacLean JE. Mask interfaces for home non-invasive ventilation in infants and children. Paediatr Respir Rev. 2019 Nov;32:66-72.
Arora B, Mahajan P, Zidan MA, Sethuraman U. Nasopharyngeal airway pressures in bronchiolitis patients treated with high-flow nasal cannula oxygen therapy. Pediatr Emerg Care. 2012 Nov;28(11):1179-84.
Ojha S, Gridley E, Dorling J. Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey. Acta Paediatr. 2013 Mar;102(3):249-53.
Spentzas T, Minarik M, Patters AB, Vinson B, Stidham G. Children with respiratory distress treated with high-flow nasal cannula. J Intensive Care Med. 2009 Sep-Oct;24(5):323-8.
McGinley BM, Patil SP, Kirkness JP, Smith PL, Schwartz AR, Schneider H. A nasal cannula can be used to treat obstructive sleep apnea. Am J Respir Crit Care Med. 2007 Jul 15;176(2):194-200.
Weiler T, Kamerkar A, Hotz J, Ross PA, Newth CJL, Khemani RG. The Relationship between High Flow Nasal Cannula Flow Rate and Effort of Breathing in Children. J Pediatr. 2017 Oct;189:66-71.e3.










